ISDA: 7D1O

Deposition Date 2020-09-15

Release Date 2020-09-23

Last Version Date 2024-11-20

Entry Detail

PDB ID:

7D1O

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SARS-Cov-2 main protease with narlaprevir

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli k-12

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.78 Å

R-Value Free:

0.24

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase
Chain IDs:A
Chain Length:306
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409

Ligand Molecules

NNA

Primary Citation

Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.

Bai, Y, Ye, F, Feng, Y, Liao, H, Song, H, Qi, J, Gao, G.F, Tan, W, Fu, L, Shi, Y.Show

Signal Transduct Target Ther 6 51 51 (2021)

PMID: 33542181 DOI: 10.1038/s41392-021-00468-9

Primary Citation of related structures

Feedback Form