ISDA: 7C2E

Deposition Date 2020-05-07

Release Date 2020-08-26

Last Version Date 2025-07-02

Entry Detail

PDB ID:

7C2E

Keywords:

MEMBRANE PROTEIN

Title:

GLP-1R-Gs complex structure with a small molecule full agonist

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)

Expression System(s):

Spodoptera frugiperda, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63092 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF00400, PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody 35|Lama glama
Chain IDs:D (auth: N)
Chain Length:138
Number of Molecules:1
Biological Source:Lama glama

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Mutagens:L260F
Chain IDs:E (auth: R)
Chain Length:491
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43220 Pfam ID:PF02793, PF00002

Ligand Molecules