ISDA: 7AEN

Deposition Date 2020-09-17

Release Date 2021-07-28

Last Version Date 2024-01-31

Entry Detail

PDB ID:

7AEN

Keywords:

SUGAR BINDING PROTEIN

Title:

Galectin-8 N-terminal carbohydrate recognition domain in complex with methyl 3-O-((7-carboxy)quinolin-2-yl)-methoxy)-beta-D-galactopyranoside

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.60 Å

R-Value Free:

0.21

R-Value Work:

0.13

R-Value Observed:

0.14

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2 of Galectin-8
Gene (Uniprot):LGALS8
Chain IDs:A, B
Chain Length:150
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O00214 Pfam ID:PF00337

Ligand Molecules

GOL

R8B

Primary Citation

Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain

Hassan, M, Baussiere, F, Guzelj, S, Sundin, A.P, Hakansson, M, Kovacic, R, Leffler, H, Tomasic, T, Anderluh, M, Jakopin, Z, Nilsson, U.J.Show

Acs Med.Chem.Lett. 12 1745 1752 (2021)

DOI: 10.1021/acsmedchemlett.1c00371

Primary Citation of related structures

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