ISDA: 6ZFU

Deposition Date 2020-06-17

Release Date 2021-06-30

Last Version Date 2024-01-24

Entry Detail

PDB ID:

6ZFU

Keywords:

ELECTRON TRANSPORT

Title:

Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.50 Å

R-Value Free:

0.23

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 65 2 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRC1
Chain IDs:A
Chain Length:444
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P31800 Pfam ID:PF00675, PF05193 EC:7.1.1.8

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRC2
Chain IDs:B
Chain Length:420
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P23004 Pfam ID:PF00675, PF05193

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b
Gene (Uniprot):MT-CYB
Chain IDs:C
Chain Length:378
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P00157 Pfam ID:PF00033, PF00032

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c1, heme protein,
Gene (Uniprot):CYC1
Chain IDs:D
Chain Length:239
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P00125 Pfam ID:PF02167

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRFS1
Chain IDs:E
Chain Length:196
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P13272 Pfam ID:PF02921, PF00355, PF09165

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRB
Chain IDs:F
Chain Length:99
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P00129 Pfam ID:PF02271

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRQ
Chain IDs:G
Chain Length:74
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P13271 Pfam ID:PF02939

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRH
Chain IDs:H
Chain Length:65
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P00126 Pfam ID:PF02320

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRFS1
Chain IDs:I
Chain Length:46
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P13272 Pfam ID:PF02921, PF00355, PF09165

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCR10
Chain IDs:J
Chain Length:59
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P00130 Pfam ID:PF05365

Ligand Molecules

6PE

CDL

FES

HEC

HEM

JHE

LMT

PEE

PG4

PO4

PX4

Primary Citation

Targeting the ubiquinol-reduction (Qi) site of the mitochondrial cytochrome bc1 complex for the development of next generation quinolone antimalarials

Amporndanai, K, O'Neill, P.M, Hong, W.D, Amewu, R.K, Pidathala, C, Berry, N, Biangini, G.A, Leung, S.C, Hasnain, S.S, Antonyuk, S.V.Show

To be published ? ? ? (?)

Primary Citation of related structures

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