ISDA: 6YXX

Deposition Date 2020-05-04

Release Date 2020-10-14

Last Version Date 2024-10-23

Entry Detail

PDB ID:

6YXX

Keywords:

RIBOSOME

Title:

State A of the Trypanosoma brucei mitoribosomal large subunit assembly intermediate

Biological Source:

Source Organism(s):

Trypanosoma brucei brucei (Taxon ID: 5702)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL28m
Gene (Uniprot):Tb06.4F7.280
Chain IDs:A (auth: A1)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q586A2

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uL29m
Gene (Uniprot):Tb09.160.5240
Chain IDs:C (auth: A2)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q38EM7 Pfam ID:PF06984

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uL30m
Gene (Uniprot):TbgDal_IX4520
Chain IDs:E (auth: A3)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZY77

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL32m
Gene (Uniprot):Tb04.1H19.670
Chain IDs:H (auth: A5)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q584F4

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL35m
Gene (Uniprot):TbgDal_X2260
Chain IDs:K (auth: A8)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A1K1

Polymer Type:polyribonucleotide
Molecule:12S ribosomal RNA
Chain IDs:L (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L3 mitochon
Gene (Uniprot):Tb03.5L5.850
Chain IDs:U (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q580R4 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L4/L1 famil
Gene (Uniprot):TEOVI_000582800
Chain IDs:X (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:A0A1G4HYD1 Pfam ID:PF00573

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RIBOSOMAL_L9 domain-containin
Gene (Uniprot):Tb05.6E7.50
Chain IDs:DA (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57UC5 Pfam ID:PF01281

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L11, putati
Gene (Uniprot):30M24.135
Chain IDs:HA (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q586R9 Pfam ID:PF03946, PF00298

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal protein L13, pu
Gene (Uniprot):Tb04.5E12.380
Chain IDs:OA (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q580D5 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal_L18e/L15P domain-co
Gene (Uniprot):Tb05.6E7.1030
Chain IDs:TA (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57U68 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal protein L17, pu
Gene (Uniprot):Tb08.11J15.1100
Chain IDs:WA (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57YI7 Pfam ID:PF01196

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL19m
Gene (Uniprot):TB927.1.1210
Chain IDs:BB (auth: AT)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q4GZ98

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL20m
Gene (Uniprot):Tb11.01.1930
Chain IDs:EB (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q383R2

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL21m
Gene (Uniprot):TbgDal_VII4650
Chain IDs:GB (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZT11 Pfam ID:PF00829

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uL22m
Gene (Uniprot):TbgDal_VII3160
Chain IDs:IB (auth: AW)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZSI8 Pfam ID:PF00237

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uL23m
Gene (Uniprot):Tb11.03.0260
Chain IDs:KB (auth: AX)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q387G3

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uL24m
Gene (Uniprot):TbgDal_III1550
Chain IDs:LB (auth: AY)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZK52

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL41
Gene (Uniprot):Tb11.01.1600
Chain IDs:QB (auth: Ae)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q383U6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL42
Gene (Uniprot):Tb11.01.1840
Chain IDs:RB (auth: Af)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q383S1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:L51_S25_CI-B8 domain-containi
Gene (Uniprot):Tb04.3I12.430
Chain IDs:UB (auth: Ag)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q583E5 Pfam ID:PF05047

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL49
Gene (Uniprot):Tb05.27M3.100
Chain IDs:YB (auth: Al)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57Z82

Polymer Type:polypeptide(L)
Molecule:mL52
Chain IDs:CC (auth: Ao)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL53
Gene (Uniprot):DPX39_070039500, DPX39_070040000
Chain IDs:DC (auth: Ap)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:A0A3L6L3K9

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL63
Gene (Uniprot):TbgDal_VII8230
Chain IDs:HC (auth: At)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZU82

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL64
Gene (Uniprot):TbgDal_XI13040
Chain IDs:IC (auth: Av)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A934

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL67
Gene (Uniprot):TbgDal_XI1730
Chain IDs:M (auth: BA)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A5V6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL68
Gene (Uniprot):TbgDal_X580
Chain IDs:P (auth: BB)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A135

Polymer Type:polypeptide(L)
Molecule:mL70
Chain IDs:S (auth: BD)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL71
Gene (Uniprot):Tb07.28B13.610
Chain IDs:V (auth: BE)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57WG1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tetratricopeptide repeat
Gene (Uniprot):DPX39_060043600
Chain IDs:Y (auth: BF)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:A0A3L6LA84

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL74
Gene (Uniprot):Tb10.6k15.3290
Chain IDs:BA (auth: BH)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q38AM5

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL75
Gene (Uniprot):TbgDal_X310
Chain IDs:EA (auth: BI)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A108

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL76
Gene (Uniprot):Tb11.01.2340
Chain IDs:GA (auth: BJ)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q383M2

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Chaperone protein DNAj, putat
Gene (Uniprot):TbgDal_VI2240
Chain IDs:IA (auth: BK)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZQR6 Pfam ID:PF00226

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL78
Gene (Uniprot):TbgDal_X13360
Chain IDs:KA (auth: BL)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A4P5

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL80
Gene (Uniprot):TbgDal_VI1080
Chain IDs:PA (auth: BN)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZQF0

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL81
Gene (Uniprot):TbgDal_XI6240
Chain IDs:RA (auth: BO)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A755

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Peptidyl-prolyl cis-trans iso
Gene (Uniprot):Tb07.28B13.640
Chain IDs:VA (auth: BQ)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57WF8 Pfam ID:PF00160 EC:5.2.1.8

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL84
Gene (Uniprot):Tb06.4F7.230
Chain IDs:XA (auth: BR)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q586A6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL85
Gene (Uniprot):Tb09.160.2250
Chain IDs:ZA (auth: BS)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q38FG8

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL86
Gene (Uniprot):DPX39_050048100
Chain IDs:CB (auth: BT)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:A0A3L6L8W0

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL87
Gene (Uniprot):TbgDal_XI9190
Chain IDs:FB (auth: BU)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A7Z9

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL88
Gene (Uniprot):TbgDal_VIII1510
Chain IDs:HB (auth: BV)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZUW3

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL89
Gene (Uniprot):Tb03.27F10.650
Chain IDs:JB (auth: BW)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57WW5

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Peptidyl-prolyl cis-trans iso
Gene (Uniprot):Tb11.01.1215
Chain IDs:MB (auth: BZ)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q383Y4 Pfam ID:PF00160 EC:5.2.1.8

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL93
Gene (Uniprot):TbgDal_X13710
Chain IDs:NB (auth: Ba)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A4T0

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL94
Gene (Uniprot):Tb09.160.5050
Chain IDs:OB (auth: Bb)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q38EP7

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL95
Gene (Uniprot):Tb10.26.0585
Chain IDs:PB (auth: Bc)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q389K3

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL98
Gene (Uniprot):Tb10.61.3155
Chain IDs:SB (auth: Bf)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q388M2

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF21
Gene (Uniprot):Tb07.28B13.550
Chain IDs:B (auth: E1)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57WG6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DUF4379 domain-containing pro
Gene (Uniprot):TbgDal_VII6670
Chain IDs:D (auth: E2)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZTN9 Pfam ID:PF14311

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF23
Gene (Uniprot):TbgDal_XI6640
Chain IDs:F (auth: E3)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A795

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF24
Gene (Uniprot):Tb06.2N9.90
Chain IDs:G (auth: E4)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q585A0

Polymer Type:polypeptide(L)
Molecule:mt-LAF25
Chain IDs:I (auth: E5)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:KRIPP3
Gene (Uniprot):TB927.1.1160
Chain IDs:J (auth: E6)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q4GZA2

Polymer Type:polypeptide(L)
Molecule:mt-LAF27
Chain IDs:VB (auth: E7)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:KRIPP9
Gene (Uniprot):Tb08.28L1.130
Chain IDs:WB (auth: E8)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57YZ6 Pfam ID:PF13812

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF29
Gene (Uniprot):DPX39_100137800
Chain IDs:XB (auth: E9)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:A0A3L6L206

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-EngA
Gene (Uniprot):Tb07.29D18.100
Chain IDs:N (auth: EA)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57TZ4 Pfam ID:PF01926, PF14714

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DEAD-box helicase, putative
Gene (Uniprot):TbgDal_XI14390
Chain IDs:Q (auth: EB)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:D0A9G9 Pfam ID:PF00270, PF00271

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Pseudouridylate synthase, put
Gene (Uniprot):Tb09.160.2000
Chain IDs:R (auth: EC)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q38FJ3 Pfam ID:PF00849

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF4
Gene (Uniprot):Tb11.02.3800
Chain IDs:T (auth: ED)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q385G9

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:SpoU_methylase domain-contain
Gene (Uniprot):TbgDal_IX7900
Chain IDs:W (auth: EE)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZZ65 Pfam ID:PF00588

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:SpoU_methylase domain-contain
Gene (Uniprot):TbgDal_VIII6660
Chain IDs:Z (auth: EF)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZWD9 Pfam ID:PF00588

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF7
Gene (Uniprot):Tb10.61.0430
Chain IDs:AA (auth: EG)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q387S8

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF8
Gene (Uniprot):TEOVI_000214000
Chain IDs:CA (auth: EH)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:A0A1G4IEQ9

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF12
Gene (Uniprot):TbgDal_VIII3060
Chain IDs:LA (auth: EL)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZVC0

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:GTP-binding protein, putative
Gene (Uniprot):Tb09.211.0810
Chain IDs:MA (auth: EM)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q38E75 Pfam ID:PF01926

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF14
Gene (Uniprot):TbgDal_V5380
Chain IDs:QA (auth: EN)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZPS0

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF15a
Gene (Uniprot):TbgDal_IV4790
Chain IDs:SA (auth: EO), UA (auth: EP)
Chain Length:0
Number of Molecules:2
Biological Source:Trypanosoma brucei brucei

UniProt ID:C9ZMA6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Acyl carrier protein
Gene (Uniprot):Tb03.27F10.580
Chain IDs:YA (auth: ER)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q57WW9 Pfam ID:PF00550

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lipase (Class 3)
Gene (Uniprot):DPX39_090084400
Chain IDs:AB (auth: ES)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:A0A3L6L1Y4 Pfam ID:PF01764

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mt-LAF19
Gene (Uniprot):Tb11.01.1810
Chain IDs:DB (auth: ET)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

UniProt ID:Q383S4

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:O (auth: UA), TB (auth: Uf)
Chain Length:0
Number of Molecules:2
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:FA (auth: UI), FC (auth: Ur)
Chain Length:0
Number of Molecules:2
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:JA (auth: UK)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:NA (auth: UM)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:ZB (auth: Ul)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:AC (auth: Um)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:BC (auth: Un)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:EC (auth: Up)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Polymer Type:polypeptide(L)
Molecule:UNK
Chain IDs:GC (auth: Us)
Chain Length:0
Number of Molecules:1
Biological Source:Trypanosoma brucei brucei

Ligand Molecules

ATP

GTP

NAD

PM8

Primary Citation

Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.

Jaskolowski, M, Ramrath, D.J.F, Bieri, P, Niemann, M, Mattei, S, Calderaro, S, Leibundgut, M, Horn, E.K, Boehringer, D, Schneider, A, Ban, N.Show

Mol. Cell 79 629 644.e4 (2020)

PMID: 32679035 DOI: 10.1016/j.molcel.2020.06.030

Abstact

In contrast to the bacterial translation machinery, mitoribosomes and mitochondrial translation factors are highly divergent in terms of composition and architecture. There is increasing evidence that the biogenesis of mitoribosomes is an intricate pathway, involving many assembly factors. To better understand this process, we investigated native assembly intermediates of the mitoribosomal large subunit from the human parasite Trypanosoma brucei using cryo-electron microscopy. We identify 28 assembly factors, 6 of which are homologous to bacterial and eukaryotic ribosome assembly factors. They interact with the partially folded rRNA by specifically recognizing functionally important regions such as the peptidyltransferase center. The architectural and compositional comparison of the assembly intermediates indicates a stepwise modular assembly process, during which the rRNA folds toward its mature state. During the process, several conserved GTPases and a helicase form highly intertwined interaction networks that stabilize distinct assembly intermediates. The presented structures provide general insights into mitoribosomal maturation.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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