ISDA: 6YDW

Deposition Date 2020-03-21

Release Date 2020-07-15

Last Version Date 2026-06-24

Entry Detail

PDB ID:

6YDW

Keywords:

TRANSLATION

Title:

55S mammalian mitochondrial ribosome with mtEFG1 and two tRNAMet (TI-POST)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Sus scrofa (Taxon ID: 9823)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:12S rRNA
Chain IDs:EA (auth: AA), CC (auth: BA)
Chain Length:0
Number of Molecules:2
Biological Source:Sus scrofa

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS2
Chain IDs:FA (auth: AB)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1S001 Pfam ID:PF00318

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS24
Chain IDs:GA (auth: AC)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287ANU4 Pfam ID:PF14955

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS5
Chain IDs:HA (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1SU66 Pfam ID:PF21251, PF00333, PF03719

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Chain IDs:IA (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS7
Chain IDs:JA (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZJ25 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPS9
Chain IDs:A (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LU08 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS10
Chain IDs:KA (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RUU2 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uS11m
Gene (Uniprot):MRPS11
Chain IDs:LA (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZJJ6 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:MA (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A0M3KL52 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS14
Chain IDs:NA (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A0M3KL53 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uS15m
Gene (Uniprot):MRPS15
Chain IDs:OA (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287BMP0 Pfam ID:PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S16, mi
Chain IDs:PA (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A480JTD7 Pfam ID:PF00886

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uS17m
Chain IDs:QA (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A8D1UDM1 Pfam ID:PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS18C
Chain IDs:RA (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A0M3KL54 Pfam ID:PF01084

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bS21m
Gene (Uniprot):MRPS21
Chain IDs:SA (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZNB3 Pfam ID:PF01165

Polymer Type:polyribonucleotide
Molecule:tRNAMet
Chain IDs:TA (auth: AV), VA (auth: AY)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:mRNA
Chain IDs:UA (auth: AX)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:unknown peptide
Chain IDs:WA (auth: AZ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS22
Chain IDs:XA (auth: Aa)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287AQT5 Pfam ID:PF10245

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS23
Gene (Uniprot):MRPS23
Chain IDs:YA (auth: Ab)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287AEW3 Pfam ID:PF10484

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS25
Chain IDs:ZA (auth: Ac)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A0M3KL55 Pfam ID:PF05047

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):GNRH2
Chain IDs:AB (auth: Ad)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287AY01

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS27
Chain IDs:BB (auth: Ae)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A5G2R5D6 Pfam ID:PF10037

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitoribosomal protein ms28, m
Gene (Uniprot):MRPS28
Chain IDs:DB (auth: Af)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A0M3KL56 Pfam ID:PF10246

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Death associated protein 3
Chain IDs:EB (auth: Ag)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A8D1XNL0 Pfam ID:PF10236

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS31
Chain IDs:FB (auth: Ah)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RME2 Pfam ID:PF15433

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS33
Chain IDs:GB (auth: Ai)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1V2H3 Pfam ID:PF08293

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS34
Gene (Uniprot):MRPS34
Chain IDs:HB (auth: Aj)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287AVS9 Pfam ID:PF16053

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS35
Chain IDs:IB (auth: Ak)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1SG95 Pfam ID:PF10213

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS37
Chain IDs:JB (auth: Am)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1SZV4 Pfam ID:PF06747

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Aurora kinase A interacting p
Chain IDs:KB (auth: An)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A8D2A802 Pfam ID:PF08213

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS39
Gene (Uniprot):PTCD3
Chain IDs:LB (auth: Ao)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:K7GKS8 Pfam ID:PF22330, PF13812

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18b, m
Gene (Uniprot):MRPS18B
Chain IDs:MB (auth: Ap)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:Q767K8 Pfam ID:PF01084

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:BA (auth: B0)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1U0F6 Pfam ID:PF01016

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL28
Chain IDs:CB (auth: B1)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZTW8 Pfam ID:PF00830

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL47
Chain IDs:UB (auth: B2)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1SGC7 Pfam ID:PF06984

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Chain IDs:VB (auth: B3)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A8D1MIP3 Pfam ID:PF00327

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Chain IDs:WB (auth: B4)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1ULI6 Pfam ID:PF09776

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL32
Chain IDs:XB (auth: B5)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LTC4 Pfam ID:PF01783

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Chain IDs:YB (auth: B6)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1TLP9 Pfam ID:PF00471

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:ZB (auth: B7)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1UFR4 Pfam ID:PF00468

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL35
Chain IDs:AC (auth: B8)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1SVC5

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein
Gene (Uniprot):MRPL36
Chain IDs:BC (auth: B9)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287A731 Pfam ID:PF00444

Polymer Type:polyribonucleotide
Molecule:CP tRNA-Phe
Chain IDs:DC (auth: BB)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Elongation factor G, mitochon
Gene (Uniprot):GFM1
Chain IDs:EC (auth: BC)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96RP9 Pfam ID:PF00009, PF03144, PF14492, PF03764, PF00679

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL2
Chain IDs:FC (auth: BD)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RRN2 Pfam ID:PF00181

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ICT1
Gene (Uniprot):MRPL3
Chain IDs:GC (auth: BE)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A140UHW4 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL4
Chain IDs:HC (auth: BF)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287B9C4 Pfam ID:PF00573

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL9
Chain IDs:IC (auth: BI)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LR45 Pfam ID:PF01281, PF22078, PF25131

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL10
Chain IDs:JC (auth: BJ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RWJ0 Pfam ID:PF00466

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL11
Chain IDs:KC (auth: BK)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RU54 Pfam ID:PF00298

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL13
Chain IDs:LC (auth: BN)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:K7GP19 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL14
Chain IDs:MC (auth: BO)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287BMZ6 Pfam ID:PF00238

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Chain IDs:NC (auth: BP)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL16
Chain IDs:OC (auth: BQ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RI89 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL17
Chain IDs:PC (auth: BR)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RMQ4 Pfam ID:PF01196

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL18
Chain IDs:QC (auth: BS)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZNK1 Pfam ID:PF00861

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL19
Chain IDs:B (auth: BT)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LNJ0 Pfam ID:PF01245

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL20
Chain IDs:C (auth: BU)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZU56 Pfam ID:PF00453

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:D (auth: BV)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RY70 Pfam ID:PF00829

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Chain IDs:E (auth: BW)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1TXR4 Pfam ID:PF00237

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Chain IDs:F (auth: BX)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL24
Chain IDs:G (auth: BY)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RHJ1 Pfam ID:PF00467, PF17136

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL37
Chain IDs:H (auth: Ba)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287BIV6 Pfam ID:PF07147

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL38
Chain IDs:I (auth: Bb)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RW03 Pfam ID:PF01161

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL39
Chain IDs:J (auth: Bc)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1SHP6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL40
Chain IDs:K (auth: Bd)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZP98 Pfam ID:PF09812

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:L (auth: Be)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A8D1F1K9 Pfam ID:PF09809

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL42
Chain IDs:M (auth: Bf)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287BQA1 Pfam ID:PF10210

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL43
Chain IDs:N (auth: Bg)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1S8U4 Pfam ID:PF05047

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL44
Chain IDs:O (auth: Bh)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1SR64 Pfam ID:PF22935, PF22892

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL45
Chain IDs:P (auth: Bi)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LGM5 Pfam ID:PF04280

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL46
Chain IDs:Q (auth: Bj)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1SRT0 Pfam ID:PF11788

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L48, mi
Gene (Uniprot):MRPL48
Chain IDs:R (auth: Bk)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A480J9Z6 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mrpl34
Gene (Uniprot):MRPL49
Chain IDs:S (auth: Bl)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A0R4J8D6 Pfam ID:PF05046

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL50
Chain IDs:T (auth: Bm)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3L9H6 Pfam ID:PF10501

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:U (auth: Bn)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A8D1P1C8 Pfam ID:PF10244

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL52
Chain IDs:V (auth: Bo)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1S9B7 Pfam ID:PF18699

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL53
Gene (Uniprot):MRPL53
Chain IDs:W (auth: Bp)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A341D604 Pfam ID:PF10780

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL54
Chain IDs:X (auth: Bq)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LN63 Pfam ID:PF08561

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL57
Chain IDs:Y (auth: Bt)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A287BP93 Pfam ID:PF14978

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):MRPL58
Chain IDs:Z (auth: Bu)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZJR2 Pfam ID:PF00472

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein
Gene (Uniprot):GADD45GIP1
Chain IDs:AA (auth: Bv)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A286ZXA6 Pfam ID:PF10147

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein S30, mi
Gene (Uniprot):MRPS30
Chain IDs:CA (auth: Bw)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A480QIM3 Pfam ID:PF07147

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS18A
Chain IDs:DA (auth: Bx)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RRH6 Pfam ID:PF01084

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:NB (auth: CL), OB (auth: DL), PB (auth: EL), QB (auth: FL), RB (auth: GL), SB (auth: HL), TB (auth: LL)
Chain Length:0
Number of Molecules:7
Biological Source:Sus scrofa

UniProt ID:A0A4X1U6S6 Pfam ID:PF16320, PF00542

Ligand Molecules

5GP

FME

GNP

GTP

SPM

Primary Citation

Structural insights into mammalian mitochondrial translation elongation catalyzed by mtEFG1.

Kummer, E, Ban, N.Show

Embo J. 39 e104820 e104820 (2020)

PMID: 32602580 DOI: 10.15252/embj.2020104820

Abstact

Mitochondria are eukaryotic organelles of bacterial origin where respiration takes place to produce cellular chemical energy. These reactions are catalyzed by the respiratory chain complexes located in the inner mitochondrial membrane. Notably, key components of the respiratory chain complexes are encoded on the mitochondrial chromosome and their expression relies on a dedicated mitochondrial translation machinery. Defects in the mitochondrial gene expression machinery lead to a variety of diseases in humans mostly affecting tissues with high energy demand such as the nervous system, the heart, or the muscles. The mitochondrial translation system has substantially diverged from its bacterial ancestor, including alterations in the mitoribosomal architecture, multiple changes to the set of translation factors and striking reductions in otherwise conserved tRNA elements. Although a number of structures of mitochondrial ribosomes from different species have been determined, our mechanistic understanding of the mitochondrial translation cycle remains largely unexplored. Here, we present two cryo-EM reconstructions of human mitochondrial elongation factor G1 bound to the mammalian mitochondrial ribosome at two different steps of the tRNA translocation reaction during translation elongation. Our structures explain the mechanism of tRNA and mRNA translocation on the mitoribosome, the regulation of mtEFG1 activity by the ribosomal GTPase-associated center, and the basis of decreased susceptibility of mtEFG1 to the commonly used antibiotic fusidic acid.

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Disease

Primary Citation of related structures

Abstact

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