ISDA: 6SER

Deposition Date 2019-07-30

Release Date 2020-08-26

Last Version Date 2026-08-12

Entry Detail

PDB ID:

6SER

Keywords:

LIPID TRANSPORT

Title:

Crystal structure of human STARD10

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.21

Space Group:

I 2 2 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:START domain-containing prote
Gene (Uniprot):STARD10
Chain IDs:A
Chain Length:291
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y365 Pfam ID:PF01852

Ligand Molecules

PEG

PGE

PO4

Primary Citation

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.

Carrat, G.R, Haythorne, E, Tomas, A, Haataja, L, Muller, A, Arvan, P, Piunti, A, Cheng, K, Huang, M, Pullen, T.J, Georgiadou, E, Stylianides, T, Amirruddin, N.S, Salem, V, Distaso, W, Cakebread, A, Heesom, K.J, Lewis, P.A, Hodson, D.J, Briant, L.J, Fung, A.C.H, Sessions, R.B, Alpy, F, Kong, A.P.S, Benke, P.I, Torta, F, Teo, A.K.K, Leclerc, I, Solimena, M, Wigley, D.B, Rutter, G.A.Show

Mol Metab 40 101015 101015 (2020)

PMID: 32416313 DOI: 10.1016/j.molmet.2020.101015

Primary Citation of related structures

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