6S8L image
Deposition Date 2019-07-10
Release Date 2019-11-27
Last Version Date 2024-05-15
Entry Detail
PDB ID:
6S8L
Keywords:
STRUCTURAL PROTEIN
Title:
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Trichoplusia ni, Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.80 Å
R-Value Free:
0.26
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
P 1 21 1
6S8L validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin alpha-1B chain
Gene (Uniprot):TUBA1B
Chain IDs:A
Chain Length:451
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P68363 Pfam ID:PF00091, PF03953
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin beta-3 chain
Gene (Uniprot):TUBB3
Chain IDs:B
Chain Length:450
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13509 Pfam ID:PF00091, PF03953
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Designed ankyrin repeat prote
Chain IDs:C (auth: F)
Chain Length:157
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
GDP
GTP
MG
PN6
Primary Citation
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes
Chem ? ? ? (2019)
DOI: 10.1016/j.chempr.2019.08.022
Primary Citation of related structures
6S8L
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