ISDA: 6QZV

Deposition Date 2019-03-12

Release Date 2020-09-30

Last Version Date 2024-01-24

Entry Detail

PDB ID:

6QZV

Keywords:

HYDROLASE

Title:

DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.00 Å

R-Value Free:

0.34

R-Value Work:

0.28

R-Value Observed:

0.28

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dipeptidyl peptidase 9
Gene (Uniprot):DPP9
Chain IDs:A, B, C, D
Chain Length:898
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q86TI2 Pfam ID:PF19520, PF00930, PF00326 EC:3.4.13.19

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MET-PRO
Chain IDs:E, F, G, H
Chain Length:2
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:6QZV

Primary Citation

Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

Silva-Garcia, M, Bolgi, O, Ross, B, Pilla, E, Kari, V, Killisch, M, Stark, N, Lenz, C, Spitzner, M, Gorrell, M.D, Grade, M, Urlaub, H, Dobbelstein, M, Huber, R, Geiss-Friedlander, R.Show

Biorxiv ? ? ? (2020)

DOI: 10.1101/2020.08.24.265033

Primary Citation of related structures

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