ISDA: 6Q1N

Deposition Date 2019-08-05

Release Date 2020-08-19

Last Version Date 2024-11-13

Entry Detail

PDB ID:

6Q1N

Keywords:

HYDROLASE/INHIBITOR

Title:

Glucocerebrosidase in complex with pharmacological chaperone IMX8

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Cricetulus griseus

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.53 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

C 2 2 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucosylceramidase
Chain IDs:A, B
Chain Length:497
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P04062 Pfam ID:PF02055, PF17189 EC:3.2.1.45

Ligand Molecules

EDO

NAG

P9V

SO4

Primary Citation

Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models.

Santana, A.G, Robinson, K, Vickers, C, Chen, H, Zhou, S, Boraston, A.B, Clarke, L.A, Withers, S.G.Show

To be published ? ? ? (?)

Primary Citation of related structures

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