ISDA: 6OJF

Deposition Date 2019-04-11

Release Date 2020-10-14

Last Version Date 2026-04-22

Entry Detail

PDB ID:

6OJF

Keywords:

HYDROLASE

Title:

Dimeric structure of LRRK2 GTPase domain

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.60 Å

R-Value Free:

0.15

R-Value Work:

0.14

R-Value Observed:

0.14

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat serine/th
Gene (Uniprot):LRRK2
Mutagens:K1460A, K1463A
Chain IDs:A, B
Chain Length:206
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q5S007 Pfam ID:PF08477 EC:2.7.11.1

Ligand Molecules

GDP

Primary Citation

Structural and biochemical basis of ROC-dependent activation of LRRK2

Park, Y, Wu, C, Tennessen, K, Wan, L, Hoang, N.C, Hoang, C.W, Liao, J, Hoang, Q.Q.Show

Pnas Nexus ? ? ? (2026)

DOI: 10.1093/pnasnexus/pgag112

Primary Citation of related structures

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