6NU3 image
Deposition Date 2019-01-30
Release Date 2019-04-17
Last Version Date 2024-10-23
Entry Detail
PDB ID:
6NU3
Keywords:
RIBOSOME
Title:
Structural insights into unique features of the human mitochondrial ribosome recycling
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
6NU3 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L32, mi
Gene (Uniprot):MRPL32
Chain IDs:Y (auth: 0)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BYC8 Pfam ID:PF01783
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L33, mi
Gene (Uniprot):MRPL33
Chain IDs:Z (auth: 1)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O75394 Pfam ID:PF00471
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L34, mi
Gene (Uniprot):MRPL34
Chain IDs:AA (auth: 2)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BQ48 Pfam ID:PF00468
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L35, mi
Gene (Uniprot):MRPL35
Chain IDs:BA (auth: 3)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NZE8 Pfam ID:PF01632
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L36, mi
Gene (Uniprot):MRPL36
Chain IDs:CA (auth: 4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9P0J6 Pfam ID:PF00444
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L37, mi
Gene (Uniprot):MRPL37
Chain IDs:DA (auth: 5)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BZE1 Pfam ID:PF07147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L38, mi
Gene (Uniprot):MRPL38
Chain IDs:EA (auth: 6)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96DV4 Pfam ID:PF01161
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L39, mi
Gene (Uniprot):MRPL39
Chain IDs:FA (auth: 7)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NYK5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L40, mi
Gene (Uniprot):MRPL40
Chain IDs:GA (auth: 8)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NQ50 Pfam ID:PF09812
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L41, mi
Gene (Uniprot):MRPL41
Chain IDs:HA (auth: 9)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8IXM3 Pfam ID:PF09809
Polymer Type:polyribonucleotide
Molecule:16S rRNA
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S34, mi
Gene (Uniprot):MRPS34
Chain IDs:CC (auth: A0)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:C9JJ19 Pfam ID:PF16053
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S35, mi
Gene (Uniprot):MRPS35
Chain IDs:DC (auth: A1)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82673 Pfam ID:PF10213
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil-helix-coiled-coil
Gene (Uniprot):CHCHD1
Chain IDs:EC (auth: A2)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96BP2 Pfam ID:PF06747
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Aurora kinase A-interacting p
Gene (Uniprot):AURKAIP1
Chain IDs:FC (auth: A3)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NWT8 Pfam ID:PF08213
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pentatricopeptide repeat doma
Gene (Uniprot):PTCD3
Chain IDs:GC (auth: A4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96EY7 Pfam ID:PF22330, PF13812
Polymer Type:polyribonucleotide
Molecule:12S rRNA
Chain IDs:CB (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S2, mit
Gene (Uniprot):MRPS2
Chain IDs:DB (auth: AB)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y399 Pfam ID:PF00318
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S24, mi
Gene (Uniprot):MRPS24
Chain IDs:EB (auth: AC)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96EL2 Pfam ID:PF14955
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S5, mit
Gene (Uniprot):MRPS5
Chain IDs:FB (auth: AD)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82675 Pfam ID:PF21251, PF00333, PF03719
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S6, mit
Gene (Uniprot):MRPS6
Chain IDs:GB (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82932 Pfam ID:PF01250
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S7, mit
Gene (Uniprot):MRPS7
Chain IDs:HB (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y2R9 Pfam ID:PF00177
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S9, mit
Gene (Uniprot):MRPS9
Chain IDs:IB (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82933 Pfam ID:PF00380
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S10, mi
Gene (Uniprot):MRPS10
Chain IDs:JB (auth: AH)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82664 Pfam ID:PF00338
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S11, mi
Gene (Uniprot):MRPS11
Chain IDs:KB (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82912 Pfam ID:PF00411
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S12, mi
Gene (Uniprot):MRPS12
Chain IDs:LB (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O15235 Pfam ID:PF00164
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S14, mi
Gene (Uniprot):MRPS14
Chain IDs:MB (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O60783 Pfam ID:PF00253
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S15, mi
Gene (Uniprot):MRPS15
Chain IDs:NB (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82914 Pfam ID:PF00312
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S16, mi
Gene (Uniprot):MRPS16
Chain IDs:OB (auth: AM)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y3D3 Pfam ID:PF00886
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S17, mi
Gene (Uniprot):MRPS17
Chain IDs:PB (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y2R5 Pfam ID:PF00366
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18b, m
Gene (Uniprot):MRPS18B
Chain IDs:QB (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y676 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18c, m
Gene (Uniprot):MRPS18C
Chain IDs:RB (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y3D5 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S21, mi
Gene (Uniprot):MRPS21
Chain IDs:SB (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82921 Pfam ID:PF01165
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S22, mi
Gene (Uniprot):MRPS22
Chain IDs:TB (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82650 Pfam ID:PF10245
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S23, mi
Gene (Uniprot):MRPS23
Chain IDs:UB (auth: AS)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y3D9 Pfam ID:PF10484
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S25, mi
Gene (Uniprot):MRPS25
Chain IDs:VB (auth: AT)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P82663 Pfam ID:PF05047
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S26, mi
Gene (Uniprot):MRPS26
Chain IDs:WB (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BYN8 Pfam ID:PF14943
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S27, mi
Gene (Uniprot):MRPS27
Chain IDs:XB (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q92552 Pfam ID:PF10037
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S28, mi
Gene (Uniprot):MRPS28
Chain IDs:YB (auth: AW)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y2Q9 Pfam ID:PF10246
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S29, mi
Gene (Uniprot):DAP3
Chain IDs:ZB (auth: AX)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P51398 Pfam ID:PF10236
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S31, mi
Gene (Uniprot):MRPS31
Chain IDs:AC (auth: AY)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q92665 Pfam ID:PF15433
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S33, mi
Gene (Uniprot):MRPS33
Chain IDs:BC (auth: AZ)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y291 Pfam ID:PF08293
Polymer Type:polyribonucleotide
Molecule:mt-tRNAVal
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L2, mit
Gene (Uniprot):MRPL2
Chain IDs:C (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q5T653 Pfam ID:PF00181, PF03947
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L3, mit
Gene (Uniprot):MRPL3
Chain IDs:D (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P09001 Pfam ID:PF00297
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L4, mit
Gene (Uniprot):MRPL4
Chain IDs:E (auth: F)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BYD3 Pfam ID:PF00573
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L9, mit
Gene (Uniprot):MRPL9
Chain IDs:F (auth: H)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BYD2 Pfam ID:PF01281, PF22078, PF25131
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L10, mi
Gene (Uniprot):MRPL10
Chain IDs:G (auth: I)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q7Z7H8 Pfam ID:PF00466
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L11, mi
Gene (Uniprot):MRPL11
Chain IDs:H (auth: J)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y3B7 Pfam ID:PF03946, PF00298
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L13, mi
Gene (Uniprot):MRPL13
Chain IDs:I (auth: K)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BYD1 Pfam ID:PF00572
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L14, mi
Gene (Uniprot):MRPL14
Chain IDs:J (auth: L)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q6P1L8 Pfam ID:PF00238
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L15, mi
Gene (Uniprot):MRPL15
Chain IDs:K (auth: M)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9P015 Pfam ID:PF00828
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L16, mi
Gene (Uniprot):MRPL16
Chain IDs:L (auth: N)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NX20 Pfam ID:PF00252
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L17, mi
Gene (Uniprot):MRPL17
Chain IDs:M (auth: O)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NRX2 Pfam ID:PF01196
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L18, mi
Gene (Uniprot):MRPL18
Chain IDs:N (auth: P)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H0U6 Pfam ID:PF00861
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L19, mi
Gene (Uniprot):MRPL19
Chain IDs:O (auth: Q)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P49406 Pfam ID:PF01245
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L20, mi
Gene (Uniprot):MRPL20
Chain IDs:P (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BYC9 Pfam ID:PF00453
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L21, mi
Gene (Uniprot):MRPL21
Chain IDs:Q (auth: S)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q7Z2W9 Pfam ID:PF00829
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L22, mi
Gene (Uniprot):MRPL22
Chain IDs:R (auth: T)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NWU5 Pfam ID:PF00237
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L23, mi
Gene (Uniprot):MRPL23
Chain IDs:S (auth: U)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q16540 Pfam ID:PF00276
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L24, mi
Gene (Uniprot):MRPL24
Chain IDs:T (auth: V)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96A35 Pfam ID:PF00467, PF17136
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L27, mi
Gene (Uniprot):MRPL27
Chain IDs:U (auth: W)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9P0M9 Pfam ID:PF01016
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L28, mi
Gene (Uniprot):MRPL28
Chain IDs:V (auth: X)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13084 Pfam ID:PF00830
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L47, mi
Gene (Uniprot):MRPL47
Chain IDs:W (auth: Y)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9HD33 Pfam ID:PF06984
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L30, mi
Gene (Uniprot):MRPL30
Chain IDs:X (auth: Z)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8TCC3 Pfam ID:PF00327
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L42, mi
Gene (Uniprot):MRPL42
Chain IDs:IA (auth: a)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y6G3 Pfam ID:PF10210
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L43, mi
Gene (Uniprot):MRPL43
Chain IDs:JA (auth: b)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8N983 Pfam ID:PF05047
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L44, mi
Gene (Uniprot):MRPL44
Chain IDs:KA (auth: c)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H9J2 Pfam ID:PF22935, PF22892 EC:3.1.26.-
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:cDNA FLJ61100, highly similar
Chain IDs:LA (auth: d)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BRJ2 Pfam ID:PF04280
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L46, mi
Gene (Uniprot):MRPL46
Chain IDs:MA (auth: e)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H2W6 Pfam ID:PF11788
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L48, mi
Gene (Uniprot):MRPL48
Chain IDs:NA (auth: f)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96GC5 Pfam ID:PF00338
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L49, mi
Gene (Uniprot):MRPL49
Chain IDs:OA (auth: g)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13405 Pfam ID:PF05046
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L50, mi
Gene (Uniprot):MRPL50
Chain IDs:PA (auth: h)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8N5N7 Pfam ID:PF10501
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L51, mi
Gene (Uniprot):MRPL51
Chain IDs:QA (auth: i)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q4U2R6 Pfam ID:PF10244
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L52, mi
Gene (Uniprot):MRPL52
Chain IDs:RA (auth: j)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q86TS9 Pfam ID:PF18699
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L53, mi
Gene (Uniprot):MRPL53
Chain IDs:SA (auth: k)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96EL3 Pfam ID:PF10780
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L54, mi
Gene (Uniprot):MRPL54
Chain IDs:TA (auth: l)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q6P161 Pfam ID:PF08561
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L55, mi
Gene (Uniprot):MRPL55
Chain IDs:UA (auth: m)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q7Z7F7 Pfam ID:PF09776
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein 63, mitocho
Gene (Uniprot):MRPL57
Chain IDs:VA (auth: o)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BQC6 Pfam ID:PF14978
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Peptidyl-tRNA hydrolase ICT1,
Gene (Uniprot):MRPL58
Chain IDs:WA (auth: p)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q14197 Pfam ID:PF00472 EC:3.1.1.29
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Growth arrest and DNA damage-
Gene (Uniprot):GADD45GIP1
Chain IDs:XA (auth: q)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8TAE8 Pfam ID:PF10147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein S18a, m
Gene (Uniprot):MRPS18A
Chain IDs:YA (auth: r)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NVS2 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein S30, mi
Gene (Uniprot):MRPS30
Chain IDs:ZA (auth: s)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NP92 Pfam ID:PF07147
Polymer Type:polypeptide(L)
Molecule:Unknown protein/protein exten
Chain IDs:AB (auth: t)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polyribonucleotide
Molecule:E-site tRNA
Chain IDs:BB (auth: u)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
MG
ZN
Primary Citation
Structural insights into unique features of the human mitochondrial ribosome recycling.
Proc. Natl. Acad. Sci. U.S.A. 116 8283 8288 (2019)
PMID: 30962385 DOI: 10.1073/pnas.1815675116

Abstact

Mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing proteins that are essential for oxidative phosphorylation (ATP generation). Despite their common ancestry with bacteria, the composition and structure of the human mitoribosome and its translational factors are significantly different from those of their bacterial counterparts. The mammalian mitoribosome recycling factor (RRFmt) carries a mito-specific N terminus extension (NTE), which is necessary for the function of RRFmt Here we present a 3.9-Å resolution cryo-electron microscopic (cryo-EM) structure of the human 55S mitoribosome-RRFmt complex, which reveals α-helix and loop structures for the NTE that makes multiple mito-specific interactions with functionally critical regions of the mitoribosome. These include ribosomal RNA segments that constitute the peptidyl transferase center (PTC) and those that connect PTC with the GTPase-associated center and with mitoribosomal proteins L16 and L27. Our structure reveals the presence of a tRNA in the pe/E position and a rotation of the small mitoribosomal subunit on RRFmt binding. In addition, we observe an interaction between the pe/E tRNA and a mito-specific protein, mL64. These findings help understand the unique features of mitoribosome recycling.

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Disease

Primary Citation of related structures
6NU3
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