ISDA: 6NFP

Deposition Date 2018-12-20

Release Date 2019-01-02

Last Version Date 2026-02-11

Entry Detail

PDB ID:

6NFP

Keywords:

HYDROLASE

Title:

1.7 Angstrom Resolution Crystal Structure of Arginase from Bacillus subtilis subsp. subtilis str. 168

Biological Source:

Source Organism(s):

Bacillus subtilis (strain 168) (Taxon ID: 224308)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.70 Å

R-Value Free:

0.16

R-Value Work:

0.13

R-Value Observed:

0.14

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Arginase
Gene (Uniprot):rocF
Chain IDs:A, B, C, D, E, F
Chain Length:299
Number of Molecules:6
Biological Source:Bacillus subtilis (strain 168)

UniProt ID:P39138 Pfam ID:PF00491 EC:3.5.3.1

Ligand Molecules

EDO

FMT

GOA

PEG

SO4

URE

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc 14 e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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