ISDA: 6LN1

Deposition Date 2019-12-28

Release Date 2021-10-06

Last Version Date 2024-10-30

Entry Detail

PDB ID:

6LN1

Keywords:

TRANSFERASE/TRANSFERASE INHIBITOR

Title:

A natural inhibitor of DYRK1A for treatment of diabetes mellitus

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.27

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 63

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dual specificity tyrosine-pho
Gene (Uniprot):DYRK1A
Chain IDs:A, B
Chain Length:347
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q13627 Pfam ID:PF00069 EC:2.7.12.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
PTR	A	TYR	modified residue

Ligand Molecules

EKU

Primary Citation

A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes.

Zheng, M, Zhang, Q, Zhang, C, Wu, C, Yang, K, Song, Z, Wang, Q, Li, C, Zhou, Y, Chen, J, Li, H, Chen, L.Show

Clin Transl Med 11 e494 e494 (2021)

PMID: 34323401 DOI: 10.1002/ctm2.494

Primary Citation of related structures

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