ISDA: 6HB8

Deposition Date 2018-08-09

Release Date 2019-08-28

Last Version Date 2026-09-09

Entry Detail

PDB ID:

6HB8

Keywords:

HYDROLASE

Title:

Crystal structure of OXA-517 beta-lactamase

Biological Source:

Source Organism(s):

Klebsiella pneumoniae (Taxon ID: 573)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.86 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-lactamase
Gene (Uniprot):blaOXA
Chain IDs:A, B, C, D
Chain Length:0
Number of Molecules:4
Biological Source:Klebsiella pneumoniae

UniProt ID:A0A1U8YI81 Pfam ID:PF00905 EC:3.5.2.6

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
KCX	A	LYS	modified residue

Ligand Molecules

EDO

ETX

GOL

SO4

Primary Citation

Structural and Biochemical Features of OXA-517: a Carbapenem and Expanded-Spectrum Cephalosporin Hydrolyzing OXA-48 Variant.

Dabos, L, Raczynska, J.E, Bogaerts, P, Zavala, A, Girlich, D, Bonnin, R.A, Dortet, L, Peyrat, A, Retailleau, P, Iorga, B.I, Jaskolski, M, Glupczynski, Y, Naas, T.Show

Antimicrob.Agents Chemother. 67 e0109522 e0109522 (2023)

PMID: 36648230 DOI: 10.1128/aac.01095-22

Primary Citation of related structures

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