ISDA: 6H10

Deposition Date 2018-07-10

Release Date 2020-01-29

Last Version Date 2026-07-22

Entry Detail

PDB ID:

6H10

Keywords:

OXIDOREDUCTASE

Title:

Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR073

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.10 Å

R-Value Free:

0.13

R-Value Work:

0.12

R-Value Observed:

0.12

Space Group:

P 43 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lysine-specific demethylase 4
Gene (Uniprot):KDM4D
Chain IDs:A
Chain Length:342
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q6B0I6 Pfam ID:PF02375, PF02373 EC:1.14.11.27

Ligand Molecules

EDO

EPE

FJ8

SO4

Primary Citation

Structure-based mapping of the histone-binding pocket of KDM4D using functionalized tetrazole and pyridine core compounds.

Malecki, P.H, Fassauer, G.M, Ruger, N, Schulig, L, Link, A, Krylova, O, Heinemann, U, Weiss, M.S.Show

Eur.J.Med.Chem. 276 116642 116642 (2024)

PMID: 38981336 DOI: 10.1016/j.ejmech.2024.116642

Primary Citation of related structures

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