ISDA: 6BK7

Deposition Date 2017-11-07

Release Date 2017-11-22

Last Version Date 2023-10-04

Entry Detail

PDB ID:

6BK7

Keywords:

RIBOSOMAL PROTEIN

Title:

1.83 Angstrom Resolution Crystal Structure of N-terminal Fragment (residues 1-404) of Elongation Factor G from Enterococcus faecalis

Biological Source:

Source Organism(s):

Enterococcus faecalis (strain ATCC 700802 / V583) (Taxon ID: 226185)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.83 Å

R-Value Free:

0.21

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Elongation factor G
Gene (Uniprot):fusA
Chain IDs:A, B
Chain Length:407
Number of Molecules:2
Biological Source:Enterococcus faecalis (strain ATCC 700802 / V583)

UniProt ID:Q839G9 Pfam ID:PF00009, PF03144

Ligand Molecules

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc ? e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Protein

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Disease

Primary Citation of related structures

Abstact

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