ISDA: 6B5F

Deposition Date 2017-09-29

Release Date 2017-10-18

Last Version Date 2023-10-04

Entry Detail

PDB ID:

6B5F

Keywords:

TRANSFERASE

Title:

Crystal structure of nicotinate mononucleotide-5,6-dimethylbenzimidazole phosphoribosyltransferase CobT from Yersinia enterocolitica

Biological Source:

Source Organism(s):

Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) (Taxon ID: 393305)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.95 Å

R-Value Free:

0.18

R-Value Work:

0.14

R-Value Observed:

0.15

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nicotinate-nucleotide--dimeth
Gene (Uniprot):cobT
Chain IDs:A, B
Chain Length:354
Number of Molecules:2
Biological Source:Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

UniProt ID:A1JTP8 Pfam ID:PF02277

Ligand Molecules

GOL

SO4

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc ? e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

Legend

Protein

Chemical

Disease

Primary Citation of related structures

Abstact

Feedback Form