ISDA: 5Z55

Deposition Date 2018-01-17

Release Date 2018-05-16

Last Version Date 2024-10-23

Entry Detail

PDB ID:

5Z55

Keywords:

ONCOPROTEIN

Title:

NMR Solution Structure of the Kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

Conformers Submitted:

Selection Criteria:

structures with the lowest energy

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Inactive tyrosine-protein kin
Gene (Uniprot):ROR1
Chain IDs:A
Chain Length:85
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q01973 Pfam ID:PF00051 EC:2.7.10.1

Ligand Molecules

Primary Citation

Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).

Ma, X, Zhang, Y, Liu, B, Yang, J, Hu, K.Show

Biomol NMR Assign 12 145 148 (2018)

PMID: 29313214 DOI: 10.1007/s12104-017-9797-9

Abstact

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expresses at high level in many cancers and has been suggested as a potential therapeutic target. It was reported that the Kringle (KNG) domain of ROR1 extracellular region is involved in ROR1/ROR2 heterooligomerization. Monoantibodies that target KNG domain of ROR1 could induce apoptosis of chronic lymphocytic leukemia cells. Here we present the backbone and side chain assignments of KNG domain of ROR1, which lays a foundation for its further structural and function research.

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Protein

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Disease

Primary Citation of related structures

Abstact

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