ISDA: 5VT3

Deposition Date 2017-05-15

Release Date 2017-05-31

Last Version Date 2026-03-25

Entry Detail

PDB ID:

5VT3

Keywords:

OXIDOREDUCTASE

Title:

High resolution structure of thioredoxin-disulfide reductase from Vibrio vulnificus CMCP6 in complex with NADP and FAD

Biological Source:

Source Organism(s):

Vibrio vulnificus CMCP6 (Taxon ID: 216895)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.98 Å

R-Value Free:

0.19

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Thioredoxin reductase
Chain IDs:A, B
Chain Length:322
Number of Molecules:2
Biological Source:Vibrio vulnificus CMCP6

UniProt ID:A0A1L9L8C0 EC:1.8.1.9

Ligand Molecules

CAC

FAD

GOL

NAP

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc 14 e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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