5UXE image
Deposition Date 2017-02-22
Release Date 2017-03-08
Last Version Date 2026-03-25
Entry Detail
PDB ID:
5UXE
Title:
Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P178
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.10 Å
R-Value Free:
0.22
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
C 1 2 1
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Inosine-5'-monophosphate dehy
Gene (Uniprot):guaB
Mutagens:CBS domain (residues 89-215) is replaced with SGG residues
Chain IDs:A, B, C, D
Chain Length:363
Number of Molecules:4
Biological Source:Clostridium perfringens
Primary Citation
Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding.
Acs Infect Dis. 11 442 452 (2025)
PMID: 39879323 DOI: 10.1021/acsinfecdis.4c00636
Primary Citation of related structures
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