ISDA: 5UU6

Deposition Date 2017-02-16

Release Date 2017-03-01

Last Version Date 2024-11-06

Entry Detail

PDB ID:

5UU6

Keywords:

OXIDOREDUCTASE

Title:

The crystal structure of nitroreductase A from Vibrio parahaemolyticus RIMD 2210633

Biological Source:

Source Organism(s):

Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) (Taxon ID: 223926)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.95 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADPH-flavin oxidoreductase
Gene (Uniprot):VPA1601
Chain IDs:A, B, C, D
Chain Length:243
Number of Molecules:4
Biological Source:Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

UniProt ID:Q87FS7 Pfam ID:PF00881

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
MSE	A	MET	modified residue

Ligand Molecules

FMN

GOL

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc ? e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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