ISDA: 5USX

Deposition Date 2017-02-14

Release Date 2017-02-22

Last Version Date 2024-10-16

Entry Detail

PDB ID:

5USX

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of thioredoxin-disulfide reductase from Vibrio vulnificus CMCP6 in complex with NADP and FAD

Biological Source:

Source Organism(s):

Vibrio vulnificus CMCP6 (Taxon ID: 216895)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.60 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Thioredoxin reductase
Gene (Uniprot):VV1455
Chain IDs:A, B
Chain Length:319
Number of Molecules:2
Biological Source:Vibrio vulnificus CMCP6

UniProt ID:Q7MLH2 Pfam ID:PF07992 EC:1.8.1.9

Ligand Molecules

EDO

FAD

NAP

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc ? e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

Legend

Protein

Chemical

Disease

Primary Citation of related structures

Abstact

Feedback Form