ISDA: 5US8

Deposition Date 2017-02-13

Release Date 2017-03-01

Last Version Date 2026-02-11

Entry Detail

PDB ID:

5US8

Keywords:

HYDROLASE, OXIDOREDUCTASE

Title:

2.15 Angstrom Resolution Crystal Structure of Argininosuccinate Synthase from Bordetella pertussis

Biological Source:

Source Organism(s):

Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) (Taxon ID: 257313)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.15 Å

R-Value Free:

0.20

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 64

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Argininosuccinate synthase
Gene (Uniprot):argG
Chain IDs:A, B
Chain Length:448
Number of Molecules:2
Biological Source:Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

UniProt ID:Q7VTJ9 Pfam ID:PF00764, PF20979 EC:6.3.4.5

Ligand Molecules

ADN

EPE

PGE

SO4

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc 14 e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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