ISDA: 5U47

Deposition Date 2016-12-03

Release Date 2016-12-28

Last Version Date 2026-02-11

Entry Detail

PDB ID:

5U47

Keywords:

LIPID BINDING PROTEIN

Title:

1.95 Angstrom Resolution Crystal Structure of Penicillin Binding Protein 2X from Streptococcus thermophilus

Biological Source:

Source Organism(s):

Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (Taxon ID: 264199)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.95 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.17

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Penicillin binding protein 2X
Gene (Uniprot):pbp2X
Mutagens:A551T
Chain IDs:A
Chain Length:707
Number of Molecules:1
Biological Source:Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)

UniProt ID:Q5M2U8 Pfam ID:PF03717, PF00905, PF03793

Ligand Molecules

ACT

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc 14 e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Disease

Primary Citation of related structures

Abstact

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