ISDA: 5U1O

Deposition Date 2016-11-28

Release Date 2016-12-14

Last Version Date 2026-02-11

Entry Detail

PDB ID:

5U1O

Keywords:

LIPID BINDING PROTEIN

Title:

2.3 Angstrom Resolution Crystal Structure of Glutathione Reductase from Vibrio parahaemolyticus in Complex with FAD.

Biological Source:

Source Organism(s):

Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) (Taxon ID: 223926)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.31 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glutathione reductase
Gene (Uniprot):VP0068
Chain IDs:A, B, C, D
Chain Length:458
Number of Molecules:4
Biological Source:Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

UniProt ID:Q87TK1 Pfam ID:PF07992, PF02852

Ligand Molecules

FAD

SO4

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc 14 e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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