ISDA: 5NRV

Deposition Date 2017-04-25

Release Date 2018-06-13

Last Version Date 2024-01-17

Entry Detail

PDB ID:

5NRV

Keywords:

TRANSFERASE

Title:

Human DNMT3B PWWP domain in complex with 6-dipropylamino-1-hexanol

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.08 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 32 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA (cytosine-5)-methyltransf
Gene (Uniprot):DNMT3B
Chain IDs:A (auth: D), B (auth: A)
Chain Length:150
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UBC3 Pfam ID:PF00855 EC:2.1.1.37

Ligand Molecules

96K

SO4

Primary Citation

Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors

Rondelet, G, Dal Maso, T, Maniquet, A, Themans, Q, Wouters, J.Show

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Primary Citation of related structures

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