ISDA: 5HUI

Deposition Date 2016-01-27

Release Date 2017-02-01

Last Version Date 2023-09-27

Entry Detail

PDB ID:

5HUI

Keywords:

oxidoreductase/oxidoreductase inhibitor

Title:

6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.46 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

H 3

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dihydrofolate reductase
Gene (Uniprot):DHFR
Chain IDs:A
Chain Length:186
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00374 Pfam ID:PF00186 EC:1.5.1.3

Ligand Molecules

65N

NDP

SO4

Primary Citation

Human dihydrofolate reductase ternary complex with a series of 6-substituted pyrido[3,2]pyrimidine-6-(4'-trifluoromethoxypheny)-2,4-diamines

Cody, V, Gangjee, A.Show

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Primary Citation of related structures

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