ISDA: 5HPB

Deposition Date 2016-01-20

Release Date 2017-01-25

Last Version Date 2023-09-27

Entry Detail

PDB ID:

5HPB

Keywords:

oxidoreductase/oxidoreductase inhibitor

Title:

human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.65 Å

R-Value Free:

0.29

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

H 3

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dihydrofolate reductase
Gene (Uniprot):DHFR
Chain IDs:A
Chain Length:186
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00374 Pfam ID:PF00186 EC:1.5.1.3

Ligand Molecules

63W

NDP

SO4

Primary Citation

Human dihydrofolate reductase ternary complex with a series offluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines

Cody, V, Gangjee, A.Show

To be published ? ? ? (?)

Primary Citation of related structures

Feedback Form