ISDA: 5A5I

Deposition Date 2015-06-18

Release Date 2016-08-24

Last Version Date 2024-05-08

Entry Detail

PDB ID:

5A5I

Keywords:

OXIDOREDUCTASE

Title:

Cytochrome 2C9 P450 inhibitor complex

Biological Source:

Source Organism(s):

HOMO SAPIENS (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

H 3

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:CYTOCHROME P450 2C9
Gene (Uniprot):CYP2C9
Chain IDs:A
Chain Length:477
Number of Molecules:1
Biological Source:HOMO SAPIENS

UniProt ID:P11712 Pfam ID:PF00067 EC:1.14.99.38

Ligand Molecules

HEM

XI1

Primary Citation

Discovery of a Novel Binding Pocket for Cyp 2C9 Inhibitors: Crystallography, Pharmacophore Modelling and Inhibitor Sar.

Skerratt, S.E, de Groot, M.J, Phillips, C.Show

Med.Chem.Comm. 7 813 ? (2016)

DOI: 10.1039/C6MD00011H

Primary Citation of related structures

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