ISDA: 4QAF

Deposition Date 2014-05-04

Release Date 2015-05-06

Last Version Date 2024-10-16

Entry Detail

PDB ID:

4QAF

Keywords:

TRANSPORT PROTEIN/SIGNALING PROTEIN

Title:

Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 32 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lipocalin-1
Gene (Uniprot):LCN1
Mutagens:R26V,E27G,F28A,P29L,E30R,M31C,N32L,L33A,E34G,T37I,M39T,L56H,S58K,C61S,E69S,K76I,D80I,K83I,Y87K,I89G,C101S,E104C,H106S,K108V,R111P,K114W,C153S
Chain IDs:A, D (auth: B)
Chain Length:152
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P31025 Pfam ID:PF00061

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Vascular endothelial growth f
Gene (Uniprot):VEGFA
Chain IDs:B (auth: C), C (auth: D)
Chain Length:112
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P15692 Pfam ID:PF00341

Ligand Molecules

ACT

OMA

SO4

Primary Citation

Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold

Giese, T, Skerra, A.Show

To be published ? ? ? (?)

Primary Citation of related structures

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