ISDA: 4QAE

Deposition Date 2014-05-04

Release Date 2015-05-06

Last Version Date 2024-11-06

Entry Detail

PDB ID:

4QAE

Keywords:

TRANSPORT PROTEIN/SIGNALING PROTEIN

Title:

Crystal structure of an engineered lipocalin (Anticalin) in complex with human hepcidin

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Neutrophil gelatinase-associa
Gene (Uniprot):LCN2
Mutagens:Q28H,A40E,I41V,Q49M,Y52W,K59E,S68I,L70M,F71P,R72L,K73A,K74E,D77E,W79L,I80F,R81Q,C87S,N96G,Y100G,L103R,Y106G,K125V,S127W,Y132V,K134W,I135V
Chain IDs:G (auth: A), H (auth: B), I (auth: C), J (auth: D), K (auth: E), L (auth: F)
Chain Length:188
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:P80188 Pfam ID:PF00061

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hepcidin
Gene (Uniprot):HAMP
Chain IDs:A (auth: P), B (auth: Q), C (auth: R), D (auth: S), E (auth: T), F (auth: U)
Chain Length:25
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:P81172 Pfam ID:PF06446

Ligand Molecules