4MZ8 image
Deposition Date 2013-09-29
Release Date 2014-07-16
Last Version Date 2026-03-25
Entry Detail
PDB ID:
4MZ8
Title:
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with an Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound C91
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.50 Å
R-Value Free:
0.21
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 31 2 1
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Inosine-5'-monophosphate dehy
Gene (Uniprot):guaB
Mutagens:CBS domain (residues 92-195) is replaced with G
Chain IDs:A, B, C, D
Chain Length:406
Number of Molecules:4
Biological Source:Campylobacter jejuni subsp. jejuni
Primary Citation
A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
J.Biol.Chem. 290 5893 5911 (2015)
PMID: 25572472 DOI: 10.1074/jbc.M114.619767
Primary Citation of related structures
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