4MZ1 image
Deposition Date 2013-09-28
Release Date 2014-01-01
Last Version Date 2026-03-25
Entry Detail
PDB ID:
4MZ1
Title:
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.40 Å
R-Value Free:
0.21
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
I 4 2 2
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Inosine-5'-monophosphate dehy
Gene (Uniprot):guaB
Mutagens:CBS domain (residues 92-195) is replaced with G
Chain IDs:A, B, C
Chain Length:385
Number of Molecules:3
Biological Source:Campylobacter jejuni subsp. jejuni
Primary Citation
A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
J. Biol. Chem. 290 5893 5911 (2015)
PMID: 25572472 DOI: 10.1074/jbc.M114.619767
Primary Citation of related structures
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