ISDA: 4KD5

Deposition Date 2013-04-24

Release Date 2013-05-08

Last Version Date 2026-03-25

Entry Detail

PDB ID:

4KD5

Keywords:

TRANSPORT PROTEIN

Title:

substrate binding domain of putative molybdenum ABC transporter from Clostridium difficile

Biological Source:

Source Organism(s):

Clostridium difficile (Taxon ID: 272563)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

C 2 2 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ABC-type transport system, mo
Gene (Uniprot):modA
Mutagens:delta 41
Chain IDs:A (auth: C), B (auth: A), C (auth: B), D
Chain Length:233
Number of Molecules:4
Biological Source:Clostridium difficile

UniProt ID:Q18A64 Pfam ID:PF13531

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
MSE	A	MET	SELENOMETHIONINE

Ligand Molecules

FMT

SBT

SO4

Primary Citation

A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile.

Rosas-Lemus, M, Dey, S, Minasov, G, Tan, K, Anderson, S.M, Brunzelle, J, Nocadello, S, Shabalin, I, Filippova, E, Halavaty, A, Kim, Y, Maltseva, N, Osipiuk, J, Minor, W, Joachimiak, A, Savchenko, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc 12 e0050723 e0050723 (2023)

PMID: 37747257 DOI: 10.1128/MRA.00507-23

Abstact

Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

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Disease

Primary Citation of related structures

Abstact

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