43SN image
Deposition Date 2026-07-15
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
43SN
Keywords:
MEMBRANE PROTEIN
Title:
Alpha-7 nicotinic acetylcholine receptor bound to inhibitory bicyclic peptide KP1877 in a resting state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.71 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
43SN validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Neuronal acetylcholine recept
Chain IDs:A, C, E, G, I
Chain Length:502
Number of Molecules:5
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:synthetic peptide KP1877
Chain IDs:B, D, F, H, J
Chain Length:17
Number of Molecules:5
Biological Source:synthetic construct
Ligand Molecules
NAG
Primary Citation
Screening, synthesis and structural characterization of a novel bicyclic peptide inhibiting alpha 7 nicotinic acetylcholine receptor.
Chem.Commun.(Camb.) ? ? ? (2026)
PMID: 42574057 DOI: 10.1039/d6cc03853k
Primary Citation of related structures
9LN7
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