ISDA: 43NO

Deposition Date 2026-07-09

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

43NO

Keywords:

DE NOVO PROTEIN

Title:

Crystal structure of a de novo-designed Binder targeting VEGFA

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:VEGFA_Binder-004
Chain IDs:A, B, E, F
Chain Length:130
Number of Molecules:4
Biological Source:synthetic construct

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Vascular endothelial growth f
Gene (Uniprot):VEGFA
Chain IDs:C, D, G, H
Chain Length:104
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P15692 Pfam ID:PF00341

Ligand Molecules

GOL

Primary Citation

High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation

Yu, Q.L, Guo, L.Y, Qin, X.Y, Huang, X.K, Tian, B.H, Wang, H.Z, Liu, Y, Wang, S, Lang, Y.Z, Shen, Z.H.Y, Lin, J, Chen, M.C.Show

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Primary Citation of related structures

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