38LQ image
Deposition Date 2026-09-02
Release Date 2026-10-21
Last Version Date 2026-10-21
Entry Detail
PDB ID:
38LQ
Keywords:
DNA BINDING PROTEIN/DNA
Title:
Structure of Staphylococcus aureus Y131F DNA gyrase GK-del fusion construct in complex with 20 bp DNA and OSU-276
Biological Source:
Source Organism(s):
Staphylococcus aureus (Taxon ID: 1280)
Expression System(s):
Escherichia coli bl21
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.84 Å
R-Value Free:
0.23
R-Value Work:
0.16
Space Group:
P 61
38LQ validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA gyrase subunit B,DNA gyra
Gene (Uniprot):gyrB, gyrA
Mutagens:Y123F
Chain IDs:A, B
Chain Length:693
Number of Molecules:2
Biological Source:Staphylococcus aureus
UniProt ID:P66936,Q99XG5 EC:5.6.2.2
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*AP*GP*CP*CP*GP*TP
Chain IDs:C, D
Chain Length:20
Number of Molecules:2
Biological Source:Staphylococcus aureus
Ligand Molecules
A1DMB
MN
SO4
Primary Citation
OSUAB-0276, a Novel Bacterial Topoisomerase Inhibitor (NBTI) with Dual Activity Against Bacterial and Human Type II Topoisomerases
To Be Published ? ? ? (?)
Primary Citation of related structures
38LQ
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