ISDA: 38GO

Deposition Date 2026-08-25

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

38GO

Keywords:

HYDROLASE

Title:

Crystal structure of MALT1 in complex with safimaltib

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.07 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Mucosa-associated lymphoid ti
Chain IDs:A, B
Chain Length:391
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1DY2

DMS

EDO

Primary Citation

Preclinical characterization of the potent and selective MALT1 inhibitor safimaltib in B cell lymphoma models

Philippar, U, Lu, T, Fontan, L, Xia, M, Vloemans, N, Bekkers, M, Gaudiano, M, Irrechukwu, O, van den Biggelaar, D, Perova, T, Guimerans-Lorenzo, I, Wnuk-Lipinska, K, Cornelissen, I, Van Heerden, M, Van Der Leede, B, Amssoms, K, Xu, R, Grant, J, Trella, E, Abraham, Y, Kimpe, K, Medaer, B, Greway, T, Snoeys, J, Jacobs, F, Cummings, M.D, Sun, W, Thuring, J.W, Wu, T, Gaj, S, Verbist, B, Connolly, P.J, Austin, N, Balasubramanian, S, Kinyamu-Akunda, J, Packman, K, Edwards, J.P, Elsayed, Y, Fourneau, N, Morschhauser, F, Gerecitano, J, Bussolari, J, Melnick, A, Attar, R.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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