ISDA: 37ZR

Deposition Date 2026-08-16

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

37ZR

Keywords:

DNA BINDING PROTEIN

Title:

Crystal structure of TP53 (89-293, Y220C) bound to compound 3

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.39 Å

R-Value Free:

0.29

R-Value Work:

0.22

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Cellular tumor antigen p53
Chain IDs:A (auth: AAA), B (auth: BBB)
Chain Length:206
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1DRM

Primary Citation

Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature

Stuckey, J.I, Vivat, V, Dickson, B.M, Setser, J.W, Li, Y, Cremers, C.M, Wilson, J.E, Peterle, D, Engen, J.R, Wales, T.E, Wilcken, R, Rohan, E.B, Chenail, G, Audia, J.E, Sims, R.J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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