ISDA: 37HF

Deposition Date 2026-07-21

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

37HF

Keywords:

PROTEIN BINDING

Title:

PCSK9 bound to small molecule inhibitor AZD-0780

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.07 Å

R-Value Free:

0.40

R-Value Work:

0.32

R-Value Observed:

0.33

Space Group:

P 21 2 21

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Propeptide of Proprotein conv
Chain IDs:A, C
Chain Length:122
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Proprotein convertase subtili
Mutagens:V474I, G670E
Chain IDs:B, D
Chain Length:546
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules