ISDA: 37EF

Deposition Date 2026-07-16

Release Date 2026-10-07

Last Version Date 2026-10-07

Entry Detail

PDB ID:

37EF

Keywords:

TRANSPORT PROTEIN

Title:

Discovery of Neutral and CSF Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli-pichia pastoris shuttle vector ppparg4

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.28 Å

R-Value Free:

0.19

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 21 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transthyretin
Gene (Uniprot):TTR
Chain IDs:A, B
Chain Length:127
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P02766 Pfam ID:PF00576

Ligand Molecules

A1DM6

Primary Citation

Discovery of Neutral and Cerebrospinal Fluid Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers

Wang, T, Thuma, B.A, Wisniewska, H.M, Lee Johnson, Z, Tu, M, Byrnes, L.J, Cabral, S, Canterbury, D.P, Clemens, J, Coffey, S.B, Dow, R, Dowling, M.S, Fensome, A, Fleming, J, Futatsugi, K, Kalgutkar, A.S, Korczynska, M, Kung, D.W, Lapham, K, Lavergne, S.Y, Limberakis, C, Liu, S, Londregan, A.T, Loria, P.M, Mascitti, V, Moody, A.T, Novak, J.J, Piotrowski, D.W, Sharma, R, Shavnya, A, Stock, I.A, Tess, D.A, Tsai, A.S, Wei, L, Wenzel, Z, Wu, H.Show

J.Med.Chem. ? ? ? (2026)

DOI: 10.1021/acs.jmedchem.6c02318

Primary Citation of related structures

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