ISDA: 36YD

Deposition Date 2026-07-06

Release Date 2026-10-07

Last Version Date 2026-10-07

Entry Detail

PDB ID:

36YD

Keywords:

DNA BINDING PROTEIN

Title:

S. aureus DNA Gyrase in complex with OSUAB-0276 and DNA

Biological Source:

Source Organism(s):

Staphylococcus aureus subsp. aureus N315 (Taxon ID: 158879)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.68 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA gyrase subunit B,DNA gyra
Gene (Uniprot):gyrB, gyrA
Chain IDs:C (auth: A), D (auth: B)
Chain Length:693
Number of Molecules:2
Biological Source:Staphylococcus aureus subsp. aureus N315

UniProt ID:P66937,Q99XG5 EC:5.6.2.2

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*AP*GP*CP*CP*GP*TP
Chain IDs:A (auth: C), B (auth: D)
Chain Length:20
Number of Molecules:2
Biological Source:synthetic construct

Ligand Molecules

A1DMB

Primary Citation

OSUAB-0276, a novel bacterial topoisomerase inhibitor (NBTI) with dual activity against bacterial and human type II topoisomerases

Cassel, S.R, Powell, J.W, Wheat, C.T, Tomaszewski, A.J, Dellos-Nolan, S, Landgraf, A.D, Sham, M.P, Carvajal-Moreno, J, Lu, Y, Chen, A, Bell, C.E, Wozniak, D.J, Yalowich, J.C, Mitton-Fry, M.J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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