ISDA: 36XS

Deposition Date 2026-07-06

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

36XS

Keywords:

DNA BINDING PROTEIN

Title:

Structure of MBD4 R512K/D560N on a T:G Mispair

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.57 Å

R-Value Free:

0.21

R-Value Work:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Methyl-CpG-binding domain pro
Gene (Uniprot):MBD4
Chain IDs:A
Chain Length:155
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O95243 EC:3.2.2.-

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*GP*CP*TP*GP*CP*GP*
Chain IDs:B
Chain Length:12
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*CP*CP*AP*GP*CP*GP*
Chain IDs:C
Chain Length:12
Number of Molecules:1
Biological Source:synthetic construct

Primary Citation

Structural and Functional Consequences of Arg512 Mutations in Methyl-CpG-Binding Domain Protein 4 (MBD4)

Barnes, R, Mandimutsira, C, Wang, G, Lee, S.Show

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