ISDA: 36OQ

Deposition Date 2026-06-24

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

36OQ

Keywords:

CONTRACTILE PROTEIN

Title:

Structure of rabbit actin bound to a truncated Mycalolide B analogue containing an expanded cyclohexane moiety

Biological Source:

Source Organism(s):

Oryctolagus cuniculus (Taxon ID: 9986)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.72 Å

R-Value Free:

0.22

R-Value Work:

0.17

R-Value Observed:

0.18

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Actin, alpha skeletal muscle
Chain IDs:A
Chain Length:370
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Ligand Molecules

A1DK1

ATP

EDO

LAB

Primary Citation

Actin-binding is not enough: solvent-facing substituents maximize cellular efficacy of actin-disrupting macrolide analogues

Trofimova, D, Alexander, C.K, Jiang, Y, Veeranna, K.D, Craig, A.W, Evans, A.P, Allingham, J.S.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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