ISDA: 36IU

Deposition Date 2026-06-12

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

36IU

Keywords:

NUCLEAR PROTEIN/DNA

Title:

Cryo-EM structure of BRD4 BD1 with basic patch 1 bound to acetylated nucleosomes

Biological Source:

Source Organism(s):

Xenopus laevis (Taxon ID: 8355)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.69 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Histone H3
Chain IDs:A, E
Chain Length:135
Number of Molecules:2
Biological Source:Xenopus laevis

Polymer Type:polypeptide(L)
Molecule:Histone H4
Chain IDs:B, F
Chain Length:103
Number of Molecules:2
Biological Source:Xenopus laevis

Polymer Type:polypeptide(L)
Molecule:Histone H2A type 1-B/E
Chain IDs:C, G
Chain Length:129
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Histone H2B type 1-J
Chain IDs:D, H
Chain Length:125
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (132-MER)
Chain IDs:I
Chain Length:165
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (127-MER)
Chain IDs:J
Chain Length:165
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:Isoform C of Bromodomain-cont
Chain IDs:K
Chain Length:722
Number of Molecules:1
Biological Source:Homo sapiens

Modified Residue