35UJ image
Deposition Date 2026-05-18
Release Date 2026-05-27
Last Version Date 2026-05-27
Entry Detail
PDB ID:
35UJ
Keywords:
BLOOD CLOTTING
Title:
Crystal structure of TFPI K2 domain in complex with 4D8 Fab fragment
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Macaca fascicularis (Taxon ID: 9541)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.90 Å
R-Value Free:
0.24
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 21 21 21
35UJ validation report missing
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:4D8 Heavy chain
Chain IDs:A (auth: H)
Chain Length:221
Number of Molecules:1
Biological Source:Homo sapiens
Protein Blast
Polymer Type:polypeptide(L)
Molecule:4D8 Light chain
Chain IDs:B (auth: L)
Chain Length:213
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tissue factor pathway inhibit
Chain IDs:C (auth: T)
Chain Length:71
Number of Molecules:1
Biological Source:Macaca fascicularis
UniProt ID:Q2PFV4
Primary Citation
Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B
To Be Published ? ? ? (?)
Primary Citation of related structures
35UJ
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