ISDA: 35UH

Deposition Date 2026-05-18

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

35UH

Keywords:

BLOOD CLOTTING

Title:

Crystal structure of TFPI K2 domain in complex with TFPI-23 Fab fragment

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Macaca fascicularis (Taxon ID: 9541)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.11 Å

R-Value Free:

0.27

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TFPI-23-Fab Heavy chain
Chain IDs:A, D, G, J, M, P
Chain Length:223
Number of Molecules:6
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TFPI-23-Fab Light chain
Chain IDs:B, E, H, K, N, Q
Chain Length:218
Number of Molecules:6
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tissue factor pathway inhibit
Chain IDs:C, F, I, L, O, R
Chain Length:71
Number of Molecules:6
Biological Source:Macaca fascicularis

UniProt ID:Q2PFV4

Ligand Molecules

Primary Citation

Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B

Jin, M, Hett, S, Jasuja, R, Rakhe, S, Narula, J, Tam, A, Apgar, J.R, Juo, Z.S, Mosyak, L, Holsti, M, Joyce, A, Hurst, S, Webster, R, Lin, L, Stahl, M, Pittman, D.D, Bloom, L.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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