35UA image
Deposition Date 2026-05-18
Release Date 2026-09-16
Last Version Date 2026-09-16
Entry Detail
PDB ID:
35UA
Keywords:
TRANSFERASE
Title:
Crystal structure of [1,2,4]triazolo[1,5-a]pyridine derivative bound to KIT
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.18 Å
R-Value Free:
0.23
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 1 21 1
35UA validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mast/stem cell growth factor
Gene (Uniprot):KIT
Mutagens:residues 694-752 deleted, and serine inserted between residues 753 and 754
Chain IDs:A, B, C
Chain Length:339
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:P10721 Pfam ID:PF07714 EC:2.7.10.1
Ligand Molecules
A1DMD
EDO
Primary Citation
Leveraging Structure-Based Design to Overcome Class III RTK Off-Target Activity in the Development of Selective Wild-Type KIT Inhibitors
J.Med.Chem. ? ? ? (2026)
DOI: 10.1021/acs.jmedchem.6c01334
Primary Citation of related structures
35UA
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