33CI image
Deposition Date 2026-08-09
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
33CI
Keywords:
IMMUNE SYSTEM
Title:
Cryo-EM structure of MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-58
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Escherichia coli bl21(de3), Cricetulus griseus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
33CI validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Chain IDs:A
Chain Length:296
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Chain IDs:B
Chain Length:100
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Melanoma-associated antigen 4
Chain IDs:C
Chain Length:10
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Fab VR-6 light chain
Chain IDs:F (auth: D)
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Fab VR-6 heavy chain
Chain IDs:G (auth: E)
Chain Length:277
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Fab BBM.1 light chain
Chain IDs:D (auth: F)
Chain Length:214
Number of Molecules:1
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:Fab BBM.1 heavy chain
Chain IDs:E (auth: G)
Chain Length:222
Number of Molecules:1
Biological Source:Mus musculus
Primary Citation
Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework
To Be Published ? ? ? (?)
Primary Citation of related structures
33CG
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